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PDRN, a regenerative skin care ingredient popularised by K-beauty, is moving firmly into the mainstream with 2026 launches from L’Oreal, The Ordinary, Medik8, Dior, Clinique and Primark. Spate data shows 37.2 million average monthly interactions and 609.8% year-on-year growth.
PDRN, the regenerative skin care ingredient popularised by K-beauty, has crossed into the Western mainstream, with 2026 launches spanning mass-market, luxury and science-backed brands — including L’Oreal Paris, The Ordinary, Medik8, Dior, Clinique and Primark. According to Spate’s 2026 Ingredient Trends Report, the ingredient is generating 37.2 million average monthly interactions across Google, TikTok and Instagram, with year-on-year growth of 609.8%.
PDRN, short for polydeoxyribonucleotide, is a DNA extract traditionally sourced from salmon sperm cells, though newer launches increasingly use plant-based or biotech-derived alternatives. It has been sold in Korean pharmacies for years, used both in skin care and as an injectable in clinics, according to Dr Christine Hall, Aesthetic Doctor and Korean skin care expert.
Among the confirmed 2026 launches is the L’Oreal Paris Revitalift Filler Hyaluronic PDRN+ Anti-Wrinkle Plumping Serum (RRP £31.99), which the brand says uses its own patented biotech PDRN+, described as 3,000 times smaller than a pore for improved absorption. The Ordinary has launched its first-ever eye cream, the Lacto-PDRN 4% + B9 Eye Cream (RRP £8.70), using a PDRN created through controlled fermentation of Lactobacillus rhamnosus, which the brand says was selected for targeted data specific to the eye area rather than trend appeal. Medik8’s Exo-PDRN Prismatic+ Youthful Vitality Serum (RRP £79) combines vegan PDRN with exosomes, with the brand citing clinical results for improved barrier function, brightness and firmness.
Plant-derived PDRN also features in Iconic London’s Underglaze Long-Wear PDRN Grippy Primer, extending the ingredient beyond skin care into make-up. Per the Cosmetics Business report, launches also span Dior, Clinique, Nip + Fab and high street retailer Primark. K-beauty brands Medicube, Rejuran, Anua, Genabelle and VT Cosmetics currently dominate consumer interest in PDRN, according to Spate’s data, though Western brands are now moving to challenge that lead.
Why Brands Are Rushing Into PDRN
The breadth of the launches — from £8.70 at The Ordinary to £79 at Medik8, and from luxury houses to budget high street retailer Primark — signals that PDRN is being positioned at every price tier, not confined to prestige or niche K-beauty importers. Spate predicts interest will rise a further 34.4% this year, with the report noting that the combination of volume and growth velocity “represents a formulation and positioning window” for brands.
Dr Hall said PDRN’s appeal to brands lies in how it intersects current skin care conversations: “It sits at the intersection of so many of the conversations happening in skin care right now: K-beauty, skin longevity, regeneration, hydration and barrier repair.” She added that it “gives brands an opportunity to talk about supporting skin health rather than simply targeting visible signs of ageing.”
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From Korean Pharmacies to Western Shelves
PDRN emerged from regenerative medicine and wound healing, where it has an established history as an injectable treatment. Dr Hall said the ingredient benefits from “a very compelling story because of its history in regenerative medicine and wound healing,” though she cautioned: “While we cannot and should not claim that topical PDRN carries the same regenerative benefits as the injectable form, it has its values in repairing compromised skin.”
The ingredient’s rise tracks a broader shift in skin care philosophy. “We are moving away from the idea of harsh actives, and that we always need to stimulate or exfoliate the skin, and more towards supporting the skin’s own ability to recover and maintain itself,” Hall said. Its formulation flexibility — serums, creams, eye products and now primers — has made it straightforward for brands to incorporate into everyday routines, she noted.
“PDRN has reached a really interesting point where several skin care trends are coming together.”
— Dr Christine Hall, Aesthetic Doctor and Korean skin care expert
Evidence Gaps Behind the Hype
Dr Hall stated that the evidence for topical PDRN’s efficacy is not as strong as for the injectable form. She noted topical PDRN can support hydration, calming and overall healthier-looking skin, but formulation quality — molecular characteristics, delivery systems and accompanying ingredients — matters greatly.
Brand claims for individual products, such as Medik8’s clinical results and L’Oreal’s absorption figures, are the companies’ own statements and have not been independently verified in this report. Which Western launches will displace the K-beauty brands currently dominating consumer interest also remains to be seen.
Whether PDRN Outlives the Trend Cycle
Spate forecasts continued acceleration, with interest expected to rise 34.4% this year, suggesting more launches across additional categories — the Iconic London primer already points to expansion into make-up. Industry recognition of the trend will continue at the Pure Beauty Awards’ 25th anniversary on 15 October 2026 at the Grosvenor House Hotel in London, where winners will be revealed.
The open question for brands, per Dr Hall’s comments, is whether the market rewards genuinely well-formulated PDRN products or whether the ingredient follows the familiar hype cycle of other buzzy actives as consumer attention shifts.
Key Questions
What is PDRN in skin care?
PDRN, or polydeoxyribonucleotide, is a DNA extract traditionally sourced from salmon sperm cells, with newer versions derived from plants or biotech fermentation. It originated in regenerative medicine and has been used in Korean pharmacies for years, both topically and as an injectable.
Which brands have launched PDRN products in 2026?
Confirmed launches span L’Oreal Paris, The Ordinary, Medik8, Iconic London, plus Dior, Clinique, Nip + Fab and Primark, according to Cosmetics Business.
Does topical PDRN work as well as injectable PDRN?
No — according to Dr Christine Hall, evidence for topical PDRN’s efficacy is not as strong as for the injectable form. She says topical use may support hydration, calming and healthier-looking skin, but the same regenerative benefits should not be claimed.
How popular is PDRN right now?
According to Spate’s 2026 Ingredient Trends Report, PDRN generates 37.2 million average monthly interactions across Google, TikTok and Instagram, with 609.8% year-on-year growth and a further predicted rise of 34.4% this year.
Are the new PDRN products vegan?
Many of the 2026 launches use vegan alternatives: L’Oreal’s serum uses its patented biotech PDRN+, The Ordinary’s eye cream uses fermentation-derived Lacto-PDRN, and Medik8 and Iconic London both describe their PDRN as vegan or plant-derived.
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